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FACT
Focus on Alternative and Complementary Therapies

Phytobalneotherapy using Flores Graminis (HAY) - prospective study of the transdermal absorption of coumarin

Hentschel C2, Brinkhaus B1, Lindner M1, Schindler G1, Nagel M1, Schwenk M1, Kohnen R3, Ernst E2, Hahn EG1
1Research Group for Traditional and Complementary Medicine, University of Erlangen-Nuremberg, Germany
2Centre for Complementary Medicine, University of Exeter, UK
3Institute of Psychology II, University of Erlangen-Nuremberg, Germany

Objective

Phytobalneotherapy using Flores Graminis (hay “flowers”) is a commonly employed complementary medical treatment, in particular for diseases of the musculoskeletal system. The postulated active agent in full baths (standardised oil, dissolved in water) is transdermally absorbed coumarin. In a pilot study, we have investigated the transdermal absorption of coumarin in the traditional hay bath (full bath in wet hay).

Material and methods

Prospective study conducted in 12 healthy male subjects (age: 18 to 30 years). Exclusion criteria included allergies and pre-existing diseases. The hay bath was taken for a period of 60 minutes and was followed by a rest period of 90 minutes. The target parameter was the plasma concentration of coumarin on conclusion of the hay bath and immediately following the rest period. It was determined by thin-layer and high-performance liquid chromatography.

Results

Mean age of the subjects: 25.5 ± 3.3 years, body mass index: 23.3 ± 2.3 kg/m2. Neither immediately following the hay bath, nor after the rest period was coumarin detected in the plasma.

Conclusion

The therapeutic effects of the traditional hay bath cannot be explained by the transdermal absorption of coumarin. Since side effects such as, for example, allergies caused by hay constituents may occur during phytobalneotherapy with Flores Graminis, the benefits and risks of the hay bath must be carefully weighed up.

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