Agnus castus containing preparation* on female sterility

Objective of the study and design

The effects of an agnus castus (AC) containing preparation*, were investigated in 96 women with fertility disorders in a double-blind study.

Patients and methods

38 women with secondary amenorrhoea, 31 women with luteal insufficiency and 27 women with idiopathic sterility received AC or placebo over a period of three months.

Target criterion and results

The target criterion, which was a pregnancy or menstrual bleeding in women with amenorrhoea and pregnancy or improved concentrations of luteal hormones in both other groups, was achieved in 30 out of 66 women (45.5%) who were suitable for evaluation. It was achieved significantly more often under AC compared to placebo (54.5% versus 36.4%, p = 0.049). 15 women conceived during the observation period (7 with amenorrhoea, 4 with idiopathic sterility, 4 with luteal insufficiency). In women with amenorrhoea or luteal insufficiency, pregnancy occurred more than twice as often under AC than on placebo. No hormonal changes were found at a 5% significance level. Altogether, 4 statements (AC: 1; placebo: 3) of adverse events such as mastodynia, depressive moods and allergic exanthema were made.

Conclusion

In women with sterility due to secondary amenorrhoea and luteal insufficiency, a treatment with AC can be recommended over a period of three to six months.

* Mastodynon^®, Manufacturer: Bionorica Arzneimittel GmbH