Focus on Alternative and Complementary Therapies
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Focus Alternat Complement Ther©2005 Pharmaceutical Press
Focus Altern Complement Ther 2003; 8: 156
To investigate interaction between Coffea cruda 30c and caffeine from two standpoints: (1) C. cruda effect on caffeine pre-administered subjects; (2) C. cruda effect plus post-caffeine treatment.
The after-effect was evaluated by means of two parameters extracted from EEG recorded during the sleep cycle of male Wistar rats. Caffeine (15 mg/kg i.p.) was pre-/post-Coffea cruda administered to Sets (1) and (2) respectively at the beginning of their sleeping period. C. cruda 30c (0.1 ml) was provided orally; in both sets, a control group was tested simultaneously. To analyse the modifications of sleep pattern, the spectral density in delta (0.5–2.5 Hz) and slow (c. 0.3 Hz) bands were evaluated vs. time for control and homoeopathic stimulated groups under a double-blind protocol.
In Set (1), a similar logarithmic pattern was identified for both, control and verum groups up to the 4th hour. From the 5th hour onwards, power in the delta band (percentage) was statistically higher in verum group; spectral power in slow band for homoeopathic-treated group was lower than control parameter from the 6th hour onwards. In Set (2) the relevant finding was the identification of two verum sub-groups: 2b–above, no significant differences from control were observed; 2b–below, variations from control were detected in the opposite direction than verum in Set (1).
According to results, C. cruda 30c modifies sleep pattern, maintaining the increase of sleep intensity in time defined as the spectral power in delta band.
