A total of 160 patients in a palliative care hospital with a life expectancy of less than 3 months were interviewed with a series of standardised instruments, including the functional assessment of chronic illness therapy-spiritual well-being scale, the Hamilton depression rating scale, the Beck hopelessness scale, and the schedule of attitudes towards hastened death. Suicidal ideation was based on responses to the Hamilton depression rating scale. Significant correlations were seen between spiritual well-being and desire for hastened death (r = – 0.51), hopelessness (r = – 0.68), and suicidal ideation (r = – 0.41). Results of multiple regression analyses showed that spiritual well-being was the strongest predictor of each outcome variable and provided a unique significant contribution beyond that of depression and relevant covariates. In addition, depression was highly correlated with desire for hastened death in participants low in spiritual well-being (r = 0.40) but not in those high in spiritual well-being (r = 0.20). The authors concluded that spiritual well-being offers some protection against end-of-life despair in those for whom death is imminent.