Japanese researchers investigated the efficacy of Rokumigan (TJ-87) and Hachimijiogan (TJ-7) in an uncontrolled study with 20 patients suffering from prolonged partial remitted major depressive disorder associated with fatigue or loss of energy. In these 20 patients, TJ-7 or TJ-87 was added to the previous regimen for 4 weeks. Six patients were ‘much improved’, six were ‘minimally improved’ (responders) and eight showed ‘no change’ (non-responders) on the CGI Global Improvement scale. All responders had Shofuku-fujin (tenderness or weakness of the lower abdomen).