The purpose of the study was to examine the prevalence and characteristics of the utilisation of CAM by patients with multiple sclerosis (MS). One hundred and fifty-four MS patients were interviewed to collect socio-demographic and disease-related variables as well as aspects of their usage of CAM. The investigation was completed by data from neurological examinations. At the time of the investigation 61.7% (n = 95) of the MS patients reported that they were currently using CAM. Most (90.3%; n = 205) of the 227 therapies utilised were complementary and only 9.7% (n = 22) were alternative choices. Users of CAM were more severely affected by the disease than non-users, but no socio-demographic differences between users and non-users were found. Concerning the efficacy of CAM, 65.8% (n = 146) of MS patients reported improvement, 32.9% (n = 73) reported no influence and 1.3% (n = 3) reported worsening of their condition.