To discuss challenges concerning treatment for chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) and review CAM therapies being evaluated for this condition, a comprehensive search of articles published from 1990 to 2005 using the Pubmed and Medline databases was performed. Data were abstracted and pooled by subject. Various CAM therapies for CP/CPPS were located including biofeedback, acupuncture, hyperthermia and electrostimulation. Additionally, a variety of in vitro and in vivo studies testing herbal and nutritional supplements were found. Serenoa repens (saw palmetto) cernilton and quercetin were the most frequently tested supplements for CP/CPPS. Although many CAM therapies demonstrate positive preliminary observations as treatments for CP/CPPS, further studies, including more RCTs, are necessary for significant validation as treatment options for this complex disorder.