The aim of this study was to explore perspectives on integrating CAM into the conventional primary care setting among patients treated at a large academic family medicine clinic in Texas, USA. A multiple choice questionnaire to evaluate perspectives of 502 patients on integrating CAM into the conventional primary healthcare system was developed and administered. All collected data were statistically analysed to evaluate responses. Among study participants, 66% indicated that they had used CAM treatments during the past year, 77% responded that they would be interested in using CAM during the next year, and 55.4% replied that they would like CAM therapies to be provided in their primary care clinic. The use of CAM in primary care settings in southern Texas is widespread. However, in this primary care setting, patients would like their family physician to provide and supervise these therapies.